Umbilical cord-derived mesenchymal stem cells alleviate liver fibrosis in rats

doi:10.3748/wjg.v22.i26.6036

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 14, 2016; 22(26): 6036-6048
Published online Jul 14, 2016. doi: 10.3748/wjg.v22.i26.6036

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Figure 7 Umbilical cord-derived mesenchymal stem cells secrete IL-4 and promote Kupffer cells polarization in vitro. We isolated Kupffer cells (KCs) from DMN rats. Flow cytometry analysis showed that about 6% of the KCs were CD206 positive M2 cells; when umbilical cord-derived mesenchymal stem cells (UC-MSCs) were added into the culture medium, M2 cells increased to more than 70%. Interestingly, anti-IL-4 antibody treatment blocked the UC-MSC effect and less than 30% KCs became M2 cells.

Citation: Chai NL, Zhang XB, Chen SW, Fan KX, Linghu EQ. Umbilical cord-derived mesenchymal stem cells alleviate liver fibrosis in rats. World J Gastroenterol 2016; 22(26): 6036-6048
URL: https://www.wjgnet.com/1007-9327/full/v22/i26/6036.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i26.6036