Pulmonary complications of hepatic diseases

Table 1 Pulmonary hypertension; drug classification

Classification	Name	Mechanism of action
Endothelin receptor antagonist	Bosentan	Dual ETA and ETB receptor subtypes antagonist. Specifically, inhibition of ET-1 receptors
	Ambrisentan	Highly selective ETA receptor inhibition
	Macitentan	High affinity ETA than ETB antagonist.
Phosphodiesterase 5 inhibitors	Sildenafil	High selectivity for PD5 vs PD2, 3 and 4.
	Tadalafil	High selectivity for PD5 compared with PD1, 4, 7 and 10.
Prostanoids	Epoprostenol	Synthetic prostacyclin with potent effects of vasodilatation and platelet aggregator inhibitor.
	Treprostinil	Long acting tricyclic benzindene synthetic analogue of prostacyclin. Vasodilator and inhibits platelet inhibition.