miR-422a is an independent prognostic factor and functions as a potential tumor suppressor in colorectal cancer

Table 1 Relationship between miR-422a and clinical parameters in colorectal cancer tissues

Clinical parameter	Number of cases (n = 102)	miR-422a expression, median (min-max)	P value
Gender			0.704
Male	63	1.446 (0.074-130.774)
Female	39	1.617 (0.167-33.543)
Age (yr)			0.328
≤ median	49	1.637 (0.088-130.774)
> median	53	1.715 (0.074-21.871)
Tumor location			0.092
Colon	58	1.798 (0.088-130.774)
Rectum	44	1.887 (0.074-33.543)
Differentiation			0.150
Well	12	1.798 (0.074-130.744)
Moderate	67	1.922 (0.166-21.871)
Poor	23	2.088 (0.088-20.406)
Tumor size			0.527
≤ 5 cm	64	2.127 (0.074-130.744)
> 5 cm	38	2.353 (0.167-21.871)
Local invasion			0.004
T1–T2	55	3.257 (0.206-130.744)
T3–T4	47	1.617 (0.074-20.406)
Lymph node metastasis			0.002
No	70	2.863 (0.359-130.744)
Yes	32	1.445 (0.074-20.406)
TNM stage			< 0.001
I	23	3.877 (0.265-15.999)
II	42	3.253 (0.074-13.566)
III	37	1.445 (0.329-130.744)

Values are median (IQR: Inter-quartile range). TNM: Tumor node metastasis.