Relationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma

Table 6 Stratified analysis on the association between single nucleotide polymorphism genotype and hepatocellular carcinoma risk according to drinking status

SNP	Drinking				Non-drinking
	Case	Control	OR (95%CI)1	P value1	Case	Control	OR (95%CI)1	P value1
rs2305952
TT	273	111	Reference		528	772	Reference
TC	69	33	0.82 (0.44-1.52)	0.53	140	205	1.02 (0.72-1.44)	0.93
CC	3	1	0.51 (0.03-9.74)	0.66	6	16	0.19 (0.06-0.60)	0.004a
TC/CC	72	34	0.81 (0.44-1.49)	0.49	146	221	0.91 (0.65-1.27)	0.57
rs515255
CC	145	56	Reference		263	355	Reference
TC	154	71	0.69 (0.40-1.19)	0.18	315	482	0.73 (0.54-0.99)	0.05a
TT	46	18	1.10 (0.50-2.43)	0.82	96	156	0.56 (0.36-0.86)	0.01a
TC/TT	200	89	0.77 (0.46-1.29)	0.31	411	638	0.69 (0.52-0.92)	0.01a

¹OR and 95%CI after adjusting for age, sex, nationality, smoking, family history of hepatocellular carcinoma, and hepatitis B virus infection.

^aP < 0.05 was considered statistically significant. OR: Odds ratio; CI: Confidence interval; SNPs: Single nucleotide polymorphisms.