Relationships between cell cycle pathway gene polymorphisms and risk of hepatocellular carcinoma

Table 3 Allele frequencies and genotype distribution of single nucleotide polymorphisms n (%)

SNP	Genotype	HCC patients	Control	χ2	P value of HWE
		n = 1019	n = 1138
rs2305952	TT	801 (78.61)	883 (77.59)
	TC	209 (20.51)	238 (20.91)	0.04	0.83
	CC	9 (0.88)	17 (1.49)
rs2425675	GG	632 (62.02)	724 (63.62)
	AG	348 (34.15)	374 (32.86)	0.96	0.33
	AA	39 (3.83)	40 (3.51)
rs3088440	GG	750 (73.60)	813 (71.44)
	GA	249 (24.44)	300 (26.36)	0.19	0.66
	AA	20 (1.96)	25 (2.20)
rs3917148	AA	773 (75.86)	882 (77.50)
	CA	233 (22.87)	235 (20.65)	1.32	0.25
	CC	13 (1.28)	21 (1.85)
rs3929	GG	619 (60.75)	688 (60.46)
	GC	349 (34.25)	395 (34.71)	0.03	0.86
	CC	51 (5.00)	55 (4.83)
rs6987652	GG	743 (72.91)	843 (74.08)
	AG	251 (24.63)	270 (23.73)	0.38	0.54
	AA	25 (2.45)	25 (2.20)
rs11556090	AA	622 (61.04)	749 (65.82)
	AG	352 (34.54)	346 (30.40)	0.15	0.70
	GG	45 (4.42)	43 (3.78)
rs17006625	AA	526 (51.62)	620 (54.48)
	AG	412 (40.43)	446 (39.19)	0.48	0.49
	GG	81 (7.95)	72 (6.33)
rs2070215	AA	465 (45.63)	554 (48.68)
	AG	424 (41.61)	480 (42.18)	< 0.01	1.00
	GG	130 (12.76)	104 (9.14)
rs2261360	CC	460 (45.14)	484 (42.53)
	CA	433 (42.49)	497 (43.67)	2.61	0.11
	AA	126 (12.37)	157 (13.80)
rs3176320	AA	579 (56.82)	687 (60.37)
	GA	383 (37.59)	377 (33.13)	5.05	0.02
	GG	57 (5.59)	74 (6.50)
rs3734166	AA	421 (41.32)	421 (36.99)
	GA	481 (47.20)	539 (47.36)	0.06	0.8
	GG	117 (11.48)	178 (15.64)
rs4858770	CC	445 (43.67)	465 (40.86)
	CT	461 (45.24)	515 (45.25)	0.65	0.42
	TT	113 (11.09)	158 (13.88)
rs515255	CC	408 (40.04)	411 (36.12)
	TC	469 (46.03)	553 (48.59)	0.29	0.59
	TT	142 (13.94)	174 (15.29)
rs8025774	CC	313 (30.72)	335 (29.44)
	CT	514 (50.44)	547 (48.07)	1.32	0.25
	TT	192 (18.84)	256 (22.50)

HCC: Hepatocellular carcinoma; SNP: Single nucleotide polymorphism; HWE: Hardy-Weinberg equilibrium