Nonbismuth concomitant quadruple therapy for Helicobacter pylori eradication in Chinese regions: A meta-analysis of randomized controlled trials

Table 1 Characteristics of included studies

Ref.	Inclusion criteria	Region	Diagnostic test	No. of patients (male %)	Age, yr(mean ± SD)	Intervention
Ang et al[36] (2015)	Age > 21 yr	Singapore	RUT, H, UBT	C10: 153 (47.1)	C10: 46.9 ± 14.8	10-d concomitant therapy
				S10: 154 (59.7)	S10: 47.5 ± 12.7	10-d sequential therapy
				T10: 155 (58.1)	T10: 49.8 ± 14.6	10-d triple therapy
Hsu et al[33] (2014)	Age ≥ 20 yr, PU or gastritis	Taiwan	RUT, Cu, H	C7: 102 (59.8)	C7: 53.9 ± 12.3	7-d concomitant therapy
				S10: 102 (50.9)	S10: 55.0 ± 12.0	10-d sequential therapy
				T7: 103 (60.2)	T7: 56.1 ± 14.0	7-d triple therapy
Huang et al[22] (2012)	Dyspepsia or epigastric discomfort	Taiwan	RUT, Cu, H	C10: 84 (57.1)	C10: 53.8 ± 15.2	10-d concomitant therapy
				S10: 85 (56.7)	S10: 51.3 ± 15.0	10-d sequential therapy
Tai et al[34] (2015)	Age ≥ 20 yr, PU or gastritis	Taiwan	Not reported	C7: 92 (50.0)	C7: 47.8 ± 11.6	7-d concomitant therapy
				T7: 92 (49.0)	T7: 52.8±12.8	7-d triple therapy
Wang et al[35] (2014)	PU and gastritis	China	UBT	C7: 81 (45.7)	C7: 51 ± 13	7-d concomitant therapy
				T7: 82 (42.7)	T7: 51 ± 15	7-d triple therapy
				T10: 83 (45.8)	T10: 52 ± 14	10-d triple therapy
Wu et al[20] (2010)	Patients visited GI clinics with HP infection	Taiwan	RUT, Cu, H	C10: 115(52.2)	C10: 51.8 ± 11	10-d concomitant therapy
				S10:117(52.1)	S10: 51.7 ± 12	10-d sequential therapy

Concomitant therapy: PPI, amoxicillin, clarithromycin, and metronidazole for 7-10 d; sequential therapy: PPI and amoxicillin for 5 d, followed by PPT, clarithromycin, and metronidazole (or tinidazole) for 5 d; triple therapy: PPI, amoxicillin, and clarithromycin for 7-10 d. PPI: lansoprazole, pantoprazole, or esomeprazole; GI: Gastrointestinal; PU: Peptic ulcer; C7: 7-d concomitant therapy; C10: 10-d concomitant therapy; S10: 10-d sequential therapy; T7: 7-d triple therapy; T10: 10-d triple therapy; Cu: Culture; H: Histology; RUT: Rapid urease test; UBT: Urea breath test.