Association of HER2 status with prognosis in gastric cancer patients undergoing R0 resection: A large-scale multicenter study in China

Table 2 Hazard ratios and 95% confidence intervals for the association between potential prognosis factors and gastric cancer

Characteristic	n	DFS				OS
		HR (95%CI)1	P value1	HR (95%CI)2	P value2	HR (95%CI)1	P value1	HR (95%CI)2	P value2
Age			< 0.001		< 0.001		< 0.001		< 0.001
< 60 yr	792	1		1		1		1
≥ 60 yr	772	1.58 (1.35-1.85)		1.42 (1.18-1.71)		1.60 (1.35-1.89)		1.39 (1.15-1.70)
Gender			0.674		0.992		0.976		0.651
Female	387	1		1		1		1
Male	1177	0.96 (0.80-1.15)		1.00 (0.82-1.23)		1.00 (0.82-1.21)		1.05 (0.85-1.30)
Minority			0.364		0.600		0.563		0.797
Han population	1507	1		1		1		1
Others	57	0.81 (0.51-1.28)		0.87 (0.52-1.46)		0.87 (0.54-1.40)		0.93 (0.55-1.59)
History of familial cancer			0.367		0.295		0.610		0.523
No	1157	1		1		1		1
Yes	157	1.12 (0.87-1.44)		1.15 (0.89-1.48)		1.07 (0.82-1.41)		1.09 (0.83-1.44)
Tumor location			< 0.001		0.743		0.003		0.545
Cardia	1007	1		1		1		1
Non-cardia	557	1.34 (1.14-1.57)		0.97 (0.81-1.16)		1.29 (1.09-1.53)		0.94 (0.78-1.14)
TNM stage
I	376	1				1		1
II	329	2.71 (1.92-3.83)	< 0.001	2.61 (1.76-3.87)	< 0.001	3.27 (2.21-4.83)	< 0.001	3.33 (2.14-5.18)	< 0.001
III	859	6.25 (4.64-8.44)	< 0.001	6.50 (4.57-9.23)	< 0.001	7.58 (5.37-10.70)	< 0.001	8.70 (5.83-12.98)	< 0.001
Tumor embolus			< 0.001		0.339		< 0.001		0.802
No	1175	1		1		1		1
Yes	289	1.81 (1.53-2.13)		1.10 (0.90-1.34)		1.70 (1.43-2.03)		0.97 (0.79-1.20)
Neural invasion			< 0.001		< 0.001		< 0.001		< 0.001
No	1334	1		1		1		1
Yes	230	1.90 (1.57-2.30)		1.51 (1.21-1.89)		2.06 (1.69-2.52)		1.68 (1.33-2.12)
Adjuvant chemotherapy			0.008		0.0151		0.052		0.002
No	678	1		1		1		1
Yes	886	1.24 (1.06-1.47)		0.79 (0.65-0.95)		1.19 (1.00-1.40)		0.73 (0.60-0.90)
Adjuvant radiotherapy			0.008		0.478		0.254		0.667
No	1462	1		1		1		1
Yes	102	1.46 (1.10-1.93)		1.11 (0.83-1.49)		1.20 (0.88-1.64)		0.93 (0.67-1.29)
HER2			0.561		0.105		0.898		0.118
Negative (-)	1015	1		1		1		1
Positive (+)	549	0.95 (0.81-1.12)		1.19 (0.96-1.46)		0.99 (0.83-1.18)		1.19 (0.96-1.48)

¹HRs and 95%CI with P value based on Cox proportional hazard regression model;

²Multivariable HRs and 95%CI with P value based on Cox proportional hazard regression model. Number of observations in the original data set = 1562. Number of observations used = 1313, owing to the missing value occurring in family history of cancer (249). DFS: Disease free survival; OS: Overall survival.