Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function

Table 4 High resolution esophageal manomtery and Timed barium esophagram findings: Adjusted analysis¹

Outcome	PD	LHM	POEM	P value
Eckardt score	2	-5.7 (-6.7, -4.5)	-5.6 (-6.1, -5.2)	0.94
HREM
Post-Pre basal mean pressure (mm Hg)	2	-27.5 (-30.3, -24.5)	-33.1 (-38.0, -27.6)	0.084
Post-Pre LES-IRP pressure (mm Hg)	2	-20.1 (-22.2, -17.9)	-20.9 (-24.7, -16.5)	0.76
TBE
Post-Pre height at 1 min (cm)	-2.7 (-5.1, -0.05)	-4.6 (-5.5, -3.7)	-5.4 (-7.1, -3.5)	0.21
Post-Pre width at 1 min (cm)	-1.4 (-1.9, -0.77)	-1.3 (-1.5, -1.03)	-1.7 (-2.2, -1.2)	0.28
Post-Pre volume at 1 min (cc)	-81.8 (-112.4, -44.3)	-79.3 (-92.7, -64.8)	-95.6 (-119.4, -67.6)	0.58
Post-Pre height at 5 min (cm)	-5.8 (-7.7, -3.7)	-6.0 (-6.8, -5.2)	-5.8 (-7.3, -4.1)	0.95
Post-Pre width at 5 min (cm)	-1.6 (-2.4, -0.74)	-1.5 (-1.8, -1.1)	-1.9 (-2.5, -1.3)	0.47
Post-Pre volume at 5 min (cc)	-68.2 (-89.9, -43.5)	-51.2 (-60.9, -41.0)	-64.6 (-82.0, -45.3)	0.28

¹ANOVA analysis was used to obtain adjusted means. A logarithm transformation of each outcome [ln(y -1 + min(y)] was modeled as the outcome variable with age at time of treatment, BMI and having had previous treatments as the independent variables. 2Data not available Only 3 patients in PD group had HREM testing done both pre- and post-treatment, hence this group was not included in the models. Values presented as mean (95%CI). PD: Pneumatic dilation; LHM: Laparoscopic Heller myotomy; POEM: Peroral endoscopic myotomy; HREM: High resolution esophageal manomtery; TBE: Timed barium esophagram; LES: Lower esophageal sphincter; IRP: Integrated relaxation pressure.