Mouse models for the discovery of colorectal cancer driver genes

Figure 1 Schematic of the T2/Onc transposon. The central viral promoter and splice donor (SD) promote the expression of candidate oncogenes. The bidirectional splice acceptor (SA) sites and polyadenylation (pA) sites allow for the disruption of candidate tumor suppressor gene expression. The inverted repeat direct repeat (IR/DR) sites (in pink) serve as binding sites for the SB transposase.