Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials

Table 1 Randomized, double-blind, placebo-controlled trials of calcium supplementation for prevention of colorectal adenomas

Study or subgroup1	Participants randomized	Mean age (yr)	Women	Follow-up (mo)	Amount of elemental calcium supplemented (mg/d)
Vitamin D/Calcium Polyp Prevention Study[27]	1675	59	15%	36 or 60	1200
SWOG Calcium Chemoprevention Pilot Study[47]	220	682	37%	60	1800
ECP Calcium Fibre Polyp Prevention Study[28]	439	59	37%	36	2000
Calcium Polyp Prevention Study[51,52]	930	61	28%	48	1200

¹For the Vitamin D/Calcium Polyp Prevention Study, only a subgroup was taken into account in the analysis;

²Median value. ECP: European Cancer Prevention Organisation; SWOG: Southwest Oncology Group.