Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia

doi:10.3748/wjg.v22.i18.4567

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2016; 22(18): 4567-4575
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4567

Table 4 Association of Helicobacter pylori cagA⁺ infection as detected by PCR with DNA methylation of the promoter regions of target genes in 33 esophageal and gastric biopsies

		Helicobacter pylori infection by PCR		P value
		Negative	Positive
Esophageal biopsies
DAPK	Unmethylated	14	0	0.004¹
DAPK	Methylated	10	9	0.004¹
THBS1	Unmethylated	15	2	0.057¹
THBS1	Methylated	9	7	0.057¹
CDH1	Unmethylated	11	1	0.107
CDH1	Methylated	13	8	0.107
p14	Unmethylated	18	5	0.400
p14	Methylated	6	4	0.400
Gastric biopsies
DAPK	Unmethylated	17	6	0.444
DAPK	Methylated	6	4	0.444
THBS1	Unmethylated	15	3	0.062
THBS1	Methylated	7	7	0.062
CDH1	Unmethylated	6	1	0.397
CDH1	Methylated	17	9	0.397
p14	Unmethylated	14	8	0.440
p14	Methylated	8	2	0.440

¹Statistically significant.

Citation: Herrera-Goepfert R, Oñate-Ocaña LF, Mosqueda-Vargas JL, Herrera LA, Castro C, Mendoza J, González-Barrios R. Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia. World J Gastroenterol 2016; 22(18): 4567-4575
URL: https://www.wjgnet.com/1007-9327/full/v22/i18/4567.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i18.4567