Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia

doi:10.3748/wjg.v22.i18.4567

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2016; 22(18): 4567-4575
Published online May 14, 2016. doi: 10.3748/wjg.v22.i18.4567

Table 2 Association of Helicobacter pylori cagA⁺ infection as detected by PCR, with DNA methylation of the promoter regions of target genes in the esophageal biopsies

		Helicobacter pylori infection by PCR		P value
		Negative	Positive	P value
DAPK	Unmethylated	26	2	0.003¹
DAPK	Methylated	24	16	0.003¹
THBS1	Unmethylated	30	5	0.019¹
THBS1	Methylated	20	13	0.019¹
CDH1	Unmethylated	19	3	0.097
CDH1	Methylated	31	15	0.097
p14	Unmethylated	36	9	0.091
p14	Methylated	14	9	0.091

¹Helicobacter pylori cagA⁺ status was significantly associated with methylation.

Citation: Herrera-Goepfert R, Oñate-Ocaña LF, Mosqueda-Vargas JL, Herrera LA, Castro C, Mendoza J, González-Barrios R. Methylation of DAPK and THBS1 genes in esophageal gastric-type columnar metaplasia. World J Gastroenterol 2016; 22(18): 4567-4575
URL: https://www.wjgnet.com/1007-9327/full/v22/i18/4567.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i18.4567