Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis

Table 1 Clinical and serological characteristics of the subjects in this study

	HV	CP	PDAC	P value 11	P value 22
Number	59	162	94
Age (yr)	48.2 ± 8.1	60.8 ± 14.5	66.7 ± 8.2	< 0.0001	< 0.05
Gender (F/M)	29/30	53/109	29/65	< 0.05	NS
AST (U/L)	18.4 ± 4.4	56.1 ± 246.0	39.2 ± 39.3	< 0.0001	NS
ALT (U/L)	15.3 ± 5.9	41.8 ± 156.7	42.9 ± 60.5	< 0.0005	NS
GGT (U/L)	28.0 ± 33.1	132.9 ± 317.0	98.8 ± 188.8	< 0.0001	NS
ALP (U/L)	179.5 ± 63.0	229.4 ± 92.6	325.8 ± 281.3	< 0.0001	NS
Alb (g/dL)	4.23 ± 0.22	4.18 ± 0.39	3.83 ± 0.37	NS	< 0.0005
T-Bil (mg/dL)	0.79 ± 0.29	0.88 ± 0.69	1.50 ± 3.26	NS	NS
Cr (mg/dL)	0.78 ± 0.19	0.77 ± 0.28	0.71 ± 0.19	NS	NS
T-Chol (mg/dL)	183.2 ± 26.5	202.7 ± 37.5	166.2 ± 33.0	< 0.05	< 0.0005
TG (mg/dL)	71.2 ± 25.6	120.3 ± 59.5	105.6 ± 48.0	< 0.0001	NS
CRP (mg/dL)	0.074 ± 0.119	1.98 ± 4.08	0.89 ± 2.09	< 0.0001	< 0.005
AMY (U/L)	71.5 ± 24.5	318.2 ± 1223.0	73.0 ± 44.8	< 0.0001	< 0.0001
Platelet (× 104/μL)	20.8 ± 4.7	23.9 ± 9.1	19.3 ± 6.7	< 0.05	< 0.005
CA19-9 (U/mL)	9.3 ± 7.9	38.7 ± 157.9	904.1 ± 3064.3	NS	< 0.0001
CEA (ng/mL)	1.35 ± 1.07	3.57 ± 4.72	7.31 ± 16.44	< 0.0005	NS
Mac-2bp (μg/mL)	1.33 ± 0.72	2.30 ± 1.75	1.32 ± 0.95	< 0.0001	< 0.0001

¹P values (Wilcoxon test) correspond to the comparison between HV and CP;

²P values correspond to the comparison between PDAC and CP. HV: Healthy volunteers; CP: Chronic pancreatitis patients; PDAC: Pancreatic ductal adenocarcinoma patients; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; GGT: γ-glutamyltransferase; ALP: Alkaline phosphatase; Alb: Albumin; T-Bil: Total bilirubin; Cr: Creatinine; T-Chol: Total cholesterol; TG: Triglyceride; CRP: C-reactive protein; AMY: Amylase; CEA: Carcinoembryonic antigen; Mac-2bp: Mac-2 binding protein; NS: Not significant.