Clinicopathological features of familial adenomatous polyposis in Korean patients

Table 1 Main characteristics of the patients with or without colorectal cancer (n = 135)

	Total(n = 135)	with CRC(n = 51)	without CRC (n = 84)	P value1
Age distribution2	31 (15-78)	34 (15-78)	28 (15-64)	0.002
< 20	11 (8.2)	5 (9.8)	6 (7.1)
20-39	86 (63.7)	23 (45.1)	63 (75.0)
40-59	34 (25.2)	21 (41.2)	13 (15.5)
≥ 60	4 (3.0)	2 (4.0)	2 (2.4)
Sex ratio (M:F)	1:0.78	1:0.59	1:0.91	0.239
CRC FHx	72 (53.3)	20 (39.2)	52 (61.9)	0.010
FAP FHx	39 (28.9)	7 (13.7)	32 (38.1)	0.003
Malignancy FHx	86 (63.7)	28 (54.9)	59 (70.2)	0.071
Follow-up (mo)2	54.2 (1-271)	55.5 (1-271)	53.49 (1-212)	0.855
Alive at follow-up	122 (90.4)	40 (78.4)	82 (97.6)	< 0.001
No. of polyps2	435	427	440	0.866
OP procedures				0.846
Handsewn TPC/IPAA	84 (62.2)	29 (56.8)	55 (65.5)
Stapled TPC/ IPAA	33 (24.4)	10 (19.6)	23 (27.4)
TPC/end ileostomy	8 (5.9)	8 (15.7)	0
TC	10 (7.4)	4 (7.8)	6 (7.1)
Mortality	13 (9.6)	11 (21.6)	2 (2.9)	< 0.001
Cancer specific	10 (7.4)	10 (19.6)	0
Other reason	3 (2.2)	1 (2.0)	2 (2.4)

¹Pearson χ² test or Fisher's exact test for categorical variable, t-test for continuous variable;

²Data are expressed as median (range). Data are expressed as number (%) unless otherwise stated. CRC: Colorectal cancer; FAP: Familial adenomatous polyposis; FHx: Family history; TPC/IPAA: Total proctocolectomy with ileal pouch anal anastomosis; TC: Total colectomy.