Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model

Table 5 Statistical measurements of the diagnostic performance for the binary classifier over different pairwise comparison of the investigated groups

	AUC	BT_Y	Spec (%)	Sen (%)	Acc (%)	TN	TP	FN	FP	NPV (%)	PPV (%)
Disease vs Control	0.992	0.764	96.8	96.0	96.2	92	312	13	3	87.6	99.0
HCC vs LC	0.962	0.655	98.8	89.1	92.3	85	156	19	1	81.7	99.3
HCC vs HCV	0.952	0.712	98.7	80.5	88.9	148	141	34	2	81.3	98.6
HCC vs Others	0.970	0.378	91.0	91.4	91.2	223	160	15	22	93.7	87.9
HCV vs Control	0.983	0.764	96.8	91.3	93.5	92	137	13	3	87.6	97.8
LC vs CHC	0.950	0.581	90.6	91.9	91.3	58	79	7	6	89.2	92.9
CHC vs Control	0.968	0.341	90.5	93.7	91.8	86	60	4	9	95.5	86.9
LC vs Control	1.000	0.500	100.0	100.0	100.0	95	86	0	0	100.0	100.0
HCC vs Control	1.000	0.500	100.0	100.0	100.0	95	175	0	0	100.0	100.0
HCC vs CHC	0.971	0.745	96.8	89.7	91.6	62	157	18	2	77.5	98.7

BT_Y: Best cut off computed using Youden statistics, TP: True positive; TN: True negative; FP: False positive; FN: False negative; Sen: Sensitivity; Spec: Specificity; Acc: Accuracy; PPV: Positive predictive value; NPV: Negative predictive value; HCC: Hepatocellular carcinoma; HCV: Hepatitis C virus.