Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model

doi:10.3748/wjg.v22.i16.4168

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Apr 28, 2016; 22(16): 4168-4182
Published online Apr 28, 2016. doi: 10.3748/wjg.v22.i16.4168

Table 1 Clinical data of the studied groups n (%)

	HCC (n = 192)	Cirrhotic (n = 96)	Non-cirrhotic (n = 96)	Control (n = 95)	P value
Age, mean ± SD (range)	56.7 ± 7.7^a (29-80)	54.01 ± 8.3^b (27-66)	40.54 ± 8.82^c (22-61)	33.37 ± 11^d (19-62)	< 0.001
Gender
Male	152^a (79)	67^a (70)	78^a (81)	21^b (22)	< 0.001
Female	40 ^a (21)	29^a (30)	18^a (19)	74^b (78)	< 0.001
Smoker
Yes	75^a (39)	26^ab (27)	20^b (21)	3^c (3)	< 0.001
No	117^a (61)	70^ab (73)	76^b (79)	92^c (97)	< 0.001
DM
Yes	43^a (22)	22^a (23)	8^b (8)	0^c (0)	< 0.001
No	149^a (78)	74^a (77)	88^b (92)	95^c (100)	< 0.001
HCV Ab
Present	168^a (88)	90^a (94)	96^b (100)	0^c	< 0.001
Absent	24^a (12)	6^a (6)	0^b (0)	95^c (100)	< 0.001
HBs Ag
Present	0 (0)	0 (0)	0 (0)	0 (0)	0.57
Absent	191 (100)	96 (100)	96 (100)	95 (100)	0.57
Ascites
Yes	86^a (45)	75^b (78)	0^c (0)	0^c (0)	< 0.001
No	106^a (55)	21^b (22)	96^c (100)	95^c (100)	< 0.001
Child score
A	69^a (36)	12^b (12)			< 0.001
B	69^a (36)	27^a (28)
C	49^a (28)	57^b (60)
ALT,
mean	64.79 ± 52.737	63.6 ± 42.54	63.41 ± 44.22	21.84 ± 5.04	< 0.001
(range)	(5-395)	(6-290)	(10-223)	(11-33)
median	51^a	60^a	54^a	22^b
AST,
mean	94.39 ± 105.61	53.91 ± 31.72	47.53 ± 29.04	26.68 ± 5.07	< 0.001
(range)	(16-1155)	(16-176)	(8-167)	( 15-37)
median	77^a	46.5^b	39.5^b	27^c
T-Bil,
mean	2.4 ± 2.63	3.25 ± 2.51	0.88 ± 0.49	0.79 ± 0.16	< 0.001
(range)	(0.3-25.8)	(0.2-19.7)	(0.3-5)	(0.5-1.1)
median	1.7^a	2.86^b	0.84^c	0.8^c
Albumin,
mean	3.02 ± 0.63	2.55 ± 0.51	4.28 ± 0.4	4.45 ± 0.34	< 0.001
(range)	(1.8-4.8)	(1.7-4.3)	(3.2-5.4)	(3.8-5.2)
median	3.1^a	2.5^b	4.2^c	4.5^d
AFP,
mean	3933.25 ± 16142	35.21 ± 40.1	18.19 ± 29.62		< 0.001
(range)	(1.5-114170)	(1.7-190)	(0.65-112)	0
median	152^a	17.95^b	4.6^c	0^d

^a-dGroups bearing different initials are significantly different. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; AFP: α-fetoprotein; DM: Diabetes mellitus; T-Bil: Total bilirubin.

Citation: Zekri ARN, Youssef ASED, Bakr YM, Gabr RM, Ahmed OS, Elberry MH, Mayla AM, Abouelhoda M, Bahnassy AA. Early detection of hepatocellular carcinoma co-occurring with hepatitis C virus infection: A mathematical model. World J Gastroenterol 2016; 22(16): 4168-4182
URL: https://www.wjgnet.com/1007-9327/full/v22/i16/4168.htm
DOI: https://dx.doi.org/10.3748/wjg.v22.i16.4168