Phosphatase and tensin homolog is a differential diagnostic marker between nonalcoholic and alcoholic fatty liver disease

Table 2 Demographic data, histological diagnosis of liver biopsies and phosphatase and tensin homolog expression in patients with alcoholic liver disease

Case	Age/sex	BMI (kg/m2)	Inflammation	Fibrosis	Cirrhosis	Steatosis	Score for PTEN expression
							NS	S	NS-S
Non-obese patients
1	56/F	26	-	p	-	100%	3	2	1
2	49/F	25	-	psn	-	40%	4	3	1
3	59/M	29	+	-	+	60%	3	3	0
4	57/F	27	+	-	+	80%	3	3	0
5	66/M	25	+	-	+	90%	4	3	1
6	55/F	28	+	-	+	90%	3	3	0
7	61/M	25	+	psn	+	70%	4	4	0
8	43/M	23	+	psn	+	80%	4	3	1
9	36/M	25	+	-	+	60%	3	2	1
10	41/M	24	+	psn	+	40%	4	3	1
11	64/M	21	+	-	+	10%	4	4	0
12	46/F	27	-	-	+	90%	3	3	0
13	28/F	22	+	-	+	80%	4	4	0
14	51/M	25	-	p	+	90%	4	3	1
15	43/M	20	+	psn	+	70%	3	3	0
16	54/M	20	-	psn	+	80%	4	4	0
17	36/M	23	-	psn	+	70%	3	2	1
Obese patients
18	60/M	30	-	psn	-	70%	3	3	0
19	55/F	41	-	p	-	70%	3	3	0
20	57/M	33	+	-	+	80%	3	3	0
21	55/M	30	+	-	+	70%	3	2	1
22	51/M	32	-	-	+	20%	4	4	0
23	65/M	31	-	psn	+	5%	4	4	0
24	72/M	34	+	psn	+	90%	4	4	0
25	39/M	31	+	-	+	20%	4	4	0

The intensity of the PTEN staining was scored in steatotic (S) and non-steatotic (NS) areas of liver sections. All liver sections from ALD patients were scored on a staining intensity scale from 0 to 4 with score = 4 representing the highest intensity. Difference between NS and S area (NS-S) was calculated. ND: Not determined; Ctrl: Controls; psn: Perisinusoidal; p: Portal; PTEN: Phosphatase and tensin homolog; ALD: Alcoholic liver disease.