Dual-input two-compartment pharmacokinetic model of dynamic contrast-enhanced magnetic resonance imaging in hepatocellular carcinoma

Table 2 Summary of parameter terms used in the dual-input extended Tofts model and 2-compartment exchange model

Symbol	Definition	Unit
Ctiss(t)	Concentration of tracer in the tissue	mmol/L
CA(t)	Concentration of tracer in whole blood in a major feeding artery	mmol/L
Cv(t)	Concentration of tracer in the portal vein	mmol/L
Fa	Arterial fraction of the tissue perfusion	%
HLV	Hematocrit in major (large) vessels	none
HPI	Hepatic perfusion index	none
Fp	Flow rate of the blood plasma through the intravascular plasma space	mL/mL per minute
vp	Ratio of blood plasma volume to tissue volume	%
ve	Ratio of EES volume to tissue volume	%
kep	Efflux rate constant	min-1
Ktrans	Transfer constant	min-1
PS	Endothelial permeability surface area product	mL/mL per minute
⊗	Convolution operator	None

EES: Extravascular extracellular space.