Dual-sugar tests of small intestinal permeability are poor predictors of bacterial infections and mortality in cirrhosis: A prospective study

Table 4 Predictors of the time to bacterial infection or death n (%)

	Bacterial infection or death within 1 yr	Univariate hazard ratio (95%CI)	P value	Adjusted hazard ratio3 (95%CI)	P value
MELD score1
≤ 13	5/20 (25)	1.00 (reference)	0.003	1.00 (reference)	0.02
> 13	18/26 (69)	4.45 (1.64-12.07)		3.23 (1.18-8.83)
Child-Pugh
Score1
≤ 7	1/13 (8)	1.00 (reference)	0.010	Not included
> 7	22/33 (67)	13.63 (1.83-101.73)		(not significant)
Ascites1
No	2/15 (13)	1.00 (reference)	0.003	1.00 (reference)	0.01
Yes	21/31 (68)	9.01 (2.10-38.70)		6.95 (1.59-30.28)
IL-61
≤ 35 pg/mL	4/17 (24)	1.00 (reference)	0.010	Not included
> 35 pg/mL	19/29 (66)	3.87 (1.31-11.47)		(not significant)
I-FABP12
≤ 1300 pg/mL	1/13 (8)	1.00 (reference)	0.010	Not included
> 1300 pg/mL	16/23 (70)	13.85 (1.83-105.04)		(missing data2)

¹Parameters were dichotomized according to the optimum cut-off from ROC analysis using maximum Youden index;

²Serum IFABP levels were available from 36 patients;

³Dichotomized parameters from univariate analysis were included in a forward-stepwise Cox regression model (P for inclusion < 0.05).