Resveratrol and fenofibrate ameliorate fructose-induced nonalcoholic steatohepatitis by modulation of genes expression

Figure 6 Effect of fenofibrate (100 mg/kg) and resveratrol (70 mg/kg) alone and in combination (half doses) on hepatic genes expression: SOCS-3 (A), SREBP-1c (B), FAS (C), MCD (D) and TGF-β1 (E) in fructose-induced NASH in rats. Gene expression (level of mRNA) was expressed in arbitrary units based on calculation expression level relative to the internal standard. Values are mean ± SE, n = 8-12 rats.The significance of the difference between means was tested by ANOVA followed by Tukey Kramer multiple comparisons test. ^aP < 0.05 vs control; ^bP < 0.05 vs FED; ^cP < 0.05 vs FENO; ^dP < 0.05 vs RES. FED: Fructose enriched diet; FENO: Fenofibrate; RES: Resveratrol; SOCS-3: Suppressor of cytokine signalling-3; SREBP-1c: Sterol regulatory element binding protein-1c; FAS: Fatty acid synthase; MCD: Malonyl Co-A decarboxylase.