Hepatitis B virus and hepatitis C virus play different prognostic roles in intrahepatic cholangiocarcinoma: A meta-analysis

Table 2 Subgroup meta-analysis for the correlation between hepatitis B virus infection and overall survival

Subgroup	n	Analytical model	HR	95%CI	Heterogeneity
					I2(%)	P value
Sample size
Sample size ≥ 100	5	FEM	0.72	0.65-0.81	33.3	0.200
Sample size < 100	6	FEM	0.84	0.72-0.98	28.7	0.219
Tumor type
MF, PI or IG	8	REM	0.75	0.62-0.90	51.8	0.043
MF only	3	FEM	0.74	0.64-0.85	0.00	0.709
Study region
China	8	FEM	0.75	0.69-0.82	40.7	0.107
Non-China	3	FEM	1.10	0.67-1.80	0.00	0.476
Mean age
Mean age ≥ 55	8	FEM	0.71	0.62-0.82	37.6	0.130
Mean age < 55	2	REM	0.80	0.67-0.95	59.7	0.115

FEM: Fixed-effects model; REM: Random-effects model; HR: Hazard ration; CI: Confidence interval; MF: Mass-forming; PI: Periductal infiltrating; IG: Intraductal growth.