Prediction of hepatocellular carcinoma biological behavior in patient selection for liver transplantation

Table 3 Response to therapy: comparison of outcomes following different pre-transplant strategies

Ref.	Treatment	Response assessemnt	Transplant criteria	No. of patients		Outcome		Comparison between responders and non responders	Comparison between downstaged patient vs conventional criteria
Millonig et al[187]	TACE	RECIST	UCSF	Total	116	Total	-
				Downstaging (DS)	NA	DS responders	5-yr OS = 25%		NS1
				Bridging (B)	NA	B responders	5-yr OS = 85.7%	0.02
						B non responders	5-yr OS = 51.4%
Chapman et al[212]	Resection, ablation, TACE	RECIST	Milan	Total	136	Total	-
				DS	76	DS responders	5-yr RFS = 50%		NS
				B	60	B responders	5-y RFS = 62.6%	NA
						B non responders
Vitale et al[15]	Resection, ablation, TACE	RECIST	Milan	Total	147		5-yr ITT survival = 74%
				DS	NA	DS responders	-		NA
				B	NA	B responders	5-yr ITT survival = 83%	< 0.01
						B non responders	5-yr ITT survival = 63%
Cucchetti et al[199]	Resection, ablation, TACE	mRECIST	Milan	Total	315	Total	-
				DS	53	DS responders	5-yr RR = 19.2%		NS1
				B	240	B responders	5-yr RR = 5.5%	0.017
						B non responders	5-yr RR = 19.4%
Ravaioli et al[17]	Resection, ablation, TACE	RECIST	Milan	Total	177	Total	3-yr RFS = 82%
				DS	48	DS responders	3-yr RFS = 75%		NS
				B	NA	B responders	3-yr RFS = 83%	NA
						B non responders
Yao et al[214]	Resection, ablation, TACE	mRECIST	Milan	Total	606	Total	-
				DS	118	DS responders	5-yr RFS = 90.8%		NS
				B	NA	B responders	5-yr RFS = 88%	NA
						B non responders
De Luna et al[213]	TACI	NA	Milan	Total	122	Total	3-yr OS = 82.7%
				DS	27	DS responders	3-yr OS = 84.1%		NS
				B	NA	B responders	3-yr OS = 84.7%	NA
						B non responders
Graziadei et al[190]	TACE	NA	Milan	Total	63	Total	NA
				DS	15	DS responders	4-yr OS = 41%		NA
				B	48	B responders	5-yr OS = 94%	NA
						B non responders	na
Otto et al[195]	TACE	mRECIST	Milan	Total	136	Total	-
				DS	49	DS responders	5-yr RFS = 92%	< 0.0001	NA
				B	87	B responders
						B non responders	5-yr RFS = 22%
De Giorgio et al[198]	Resection, ablation, TACE	NA	Milan	Total	206	Total	NA
				DS	NA	DS responders			NA
				B	83	B responders		NA
						B non responders

¹Computed not stastically significant. NA: Not available; NS: Not statistically significant; OS: Overall Survival; RFS: Recurrence free survival or freedom from recurrence; RR: Recurrence rate; RECIST: Response Evaluation criteria in solid tumors; mRECIST: Modified response evaluation criteria in solid tumors; TACE: Trans arterial chemo-embolization; TACI: Trans Arterial chemo-infusion; UCSF: University of California San Francisco.