Silencing profilin-1 inhibits gastric cancer progression via integrin β1/focal adhesion kinase pathway modulation

Figure 7 Schematic diagram of the mechanism underling the inhibition of gastric cancer progression through profilin-1 silencing. Profilin-1 (PFN1) silencing decreases actin filament assembly and reduces the binding among PFN1, actin and integrin β1, which inhibits the focal adhesion kinase (FAK) activation through the down regulation of integrin β1 expression. FAK inhibition through profilin-1 silencing inhibits gastric cancer progression via mitogen-activated protein kinase and phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathways. mTOR: Mammalian target of rapamycin.