Synchronous splenectomy and hepatectomy for patients with hepatocellular carcinoma and hypersplenism: A case-control study

Table 6 Univariate and multivariate analyses of prognostic factors for overall survival

Variable	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Splenectomy	0.862 (0.497-1.492)	0.595
Gender, F	0.466 (1.125-4.083)	0.020	0.774 (1.164-4.041)	0.015
Age, > 60 yr	0.876 (0.384-1.998)	0.752
HBsAg, positive	0.552 (0.259-1.176)	0.124
AFP, > 400 ng/mL	0.986 (0.563-1.728)	0.962
Platelet count	1.004 (0.995-1.013)	0.397
White blood cell count	0.975 (0.901-1.055)	0.533
Tumor number, multiple	2.216 (1.033-4.752)	0.041	0.801 (1.071-4.633)	0.032
Tumor size, > 5 cm	2.067 (1.087-3.930)	0.027	0.572 (0.991-3.169)	0.054
Micro-vascular invasion	0.624 (0.329-1.182)	0.148
Recurrence	14.376 (6.233-33.160)	< 0.001	2.344 (4.961-21.882)	< 0.001

HBsAg: Hepatitis B surface antigen; AFP: Alpha-fetoprotein.