Management of patients with hepatitis B in special populations

doi:10.3748/wjg.v21.i6.1738

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Feb 14, 2015 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 14, 2015; 21(6): 1738-1748
Published online Feb 14, 2015. doi: 10.3748/wjg.v21.i6.1738

Table 2 Dosage adjustment of nucleos(t)ides analogs in patients with chronic hepatitis B according to the creatinine (CrCl)[44]

CrCl (mL/min)	Lamivudine	Telbivudine	Adefovir	Entecavir¹	Tenofovir
≥ 50	100 mg/d	600 mg/d	10 mg/d	0.5 mg/d	245 mg/d
30-49	50 mg/d	600 mg/2^nd day	10 mg/2^nd day	0.25 mg/d	245 mg/2^nd day
10-29	25 mg/d	600 mg/3^rd day	10 mg/3^rd day	0.15 mg/d	245 mg/3^rd-4^th day
< 5-10 or HD²	10 mg/d	600 mg/3^rd-4^th day	10 mg/wk	0.5 mg/wk	245 mg/wk³

¹Recommendations only for nucleos(t)ide analog naïve patients (in lamivudine resistance the dosage is double);

²In patients undergoing HD, all agents should be given once weekly after an HD session;

³Only for patients on HD. HD: Hemodialysis.

Citation: Cholongitas E, Tziomalos K, Pipili C. Management of patients with hepatitis B in special populations. World J Gastroenterol 2015; 21(6): 1738-1748
URL: https://www.wjgnet.com/1007-9327/full/v21/i6/1738.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i6.1738