HIF-1α -1790G>A polymorphism significantly increases the risk of digestive tract cancer: A meta-analysis

Table 2 Meta-analysis results of -1772C>T polymorphism

	Dominant comparison		Allele comparison		Heterozygote comparison
	OR (95%CI)	Phet	OR (95%CI)	Phet	OR (95%CI)	Phet
Overall	1.156 (0.839-1.593)	0.007	1.325 (0.846-2.076)	< 0.001	0.853 (0.502-1.450)	< 0.001
Ethnicity
Caucasian	1.053 (0.842-1.317)	0.381	1.075 (0.795-1.454)	0.011	0.459 (0.174-1.211)	0.060
Asian	1.302 (0.748-2.266)	0.007	1.169 (0.667-2.049)	< 0.001	1.132 (0.628-2.040)	0.009
Source of control
HB	1.314 (0.884-1.954)	0.014	1.661 (0.755-3.656)	< 0.001	1.153 (0.633-2.099)	0.009
PB	0.898 (0.498-1.620)	0.086	1.163 (0.698-1.938)	0.089	0.482 (0.166-1.405)	0.004
Cancer types
OC	1.063 (0.643-1.757)	0.304	2.517 (0.705-8.980)	< 0.001	0.917 (0.444-1.895)	0.135
PC	1.388 (0.542-3.555)	0.032	1.753 (1.225-2.508)1	0.349	0.500 (0.018-14.015)	0.001
CRC	1.118 (0.573-2.182)	0.015	0.262 (0.011-6.380)	0.024	0.241 (0.011-5.509)	0.027
HWE
No	0.777 (0.466-1.296)	0.832	3.221 (0.673-15.414)	< 0.001	0.250 (0.051-1.211)	0.139
Yes	1.260 (0.873-1.818)	0.007	1.149 (0.723-1.826)	0.009	1.091 (0.660-1.803)	0.005
Sample size
Small	0.958 (0.621-1.479)	0.031	1.192 (0.680-2.089)	< 0.001	0.658 (0.362-1.197)	0.007
Large	1.569 (1.049-2.345)1	0.125	1.983 (1.325-2.969)1	0.867	1.994 (1.307-3.042)1	0.529

¹Significant association. Phet: P value of heterogeneity; HB: Hospital-based studies; PB: Population-based studies; OC: Oral cancer; PC: Pancreatic cancer; CRC: Colorectal cancer.