KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients

doi:10.3748/wjg.v21.i5.1595

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 7, 2015; 21(5): 1595-1605
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1595

Table 6 Correlations between DNA mismatch repair protein expression deficiency and KRAS or BRAF status n (%)

MMR status	KRAS (n = 432)		BRAF (n = 424)
MMR status	Mutant/tested cases	P value	Mutant/tested cases	P value
dMMR	9/48 (18.8)	0.002¹	4/43 (9.3)	0.264
MLH1/PMS2 deficiency	3/29 (10.3)	0.001²	4/26 (15.4)	0.037³
MSH2/MSH6 deficiency	6/19 (31.6)	0.383³	0/17 (0)	0.817³
pMMR	160/384 (41.7)		16/381 (4.2)

¹dMMR vs pMMR;

²MLH1/PMS2 deficiency vs pMMR;

³MSH2/MSH6 vs pMMR. MMR: DNA mismatch repair.

Citation: Ye JX, Liu Y, Qin Y, Zhong HH, Yi WN, Shi XY. KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients. World J Gastroenterol 2015; 21(5): 1595-1605
URL: https://www.wjgnet.com/1007-9327/full/v21/i5/1595.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i5.1595