KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients

doi:10.3748/wjg.v21.i5.1595

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Feb 7, 2015; 21(5): 1595-1605
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1595

Table 4 Correlations between KRAS and BRAF status and clinicopathological features n (%)

Clinicopathological feature	KRAS		BRAF
Clinicopathological feature	Mutant/tested cases	P value	Mutant/tested cases	P value
Gender
Male	100/277 (36.1)	0.336	7/254 (2.8)	0.048
Female	84/208 (40.4)	0.336	13/196 (6.6)	0.048
Age (yr)
< 50	11/50 (22)	0.014	3/47 (6.4)	0.758
≥ 50	173/435 (39.8)	0.014	17/403 (4.2)	0.758
Location
Right colon	67/161 (41.6)	0.318	14/146 (9.6)	0.001
Left colon	50/150 (33.3)		3/167 (2.1)
Rectum	68/177 (38.4)		3/140 (1.8)
Mucin production
With	41/108 (38)	0.990	10/102 (9.8)	0.006
Without	144/380 (37.9)	0.990	10/351 (2.8)	0.006
Tumor differentiation
Poor	25/84 (29.8)	0.091	7/74 (9.5)	0.045
Well-moderate	160/404 (39.6)	0.091	13/379 (3.4)	0.045
Tumor stage
I-II	85/232 (36.6)	0.553	10/218 (4.6)	0.918
III-IV	97/247 (39.3)	0.553	10/228 (4.4)	0.918

Citation: Ye JX, Liu Y, Qin Y, Zhong HH, Yi WN, Shi XY. KRAS and BRAF gene mutations and DNA mismatch repair status in Chinese colorectal carcinoma patients. World J Gastroenterol 2015; 21(5): 1595-1605
URL: https://www.wjgnet.com/1007-9327/full/v21/i5/1595.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i5.1595