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©The Author(s) 2015.
World J Gastroenterol. Feb 7, 2015; 21(5): 1457-1467
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1457
Published online Feb 7, 2015. doi: 10.3748/wjg.v21.i5.1457
Table 3 Histologic features of colorectal cancers in patients with loss of CDX2 expression n (%)
| Parameters | CDX2-retained671 (94.1) | Loss of CDX2 expression42 (5.9) | P value |
| Differentiation | < 0.0011 | ||
| Differentiated | 656 (97.8) | 31 (73.8) | |
| Undifferentiated | 15 (2.2) | 11 (26.2) | |
| Luminal necrosis | 0.0531 | ||
| Absent | 61 (9.1) | 8 (19.1) | |
| Present | 610 (90.9) | 34 (80.9) | |
| Tumor budding | > 0.9991 | ||
| Absent | 29 (4.3) | 1 (2.4) | |
| Present | 642 (95.7) | 41 (97.6) | |
| Tumor-infiltrating lymphocytes | 0.013 | ||
| Low (< 8/HPF) | 513 (76.4) | 25 (59.5) | |
| High (≥ 8/HPF) | 158 (23.6) | 17 (40.5) | |
| Crohn’s-like lymphoid reaction | < 0.0011 | ||
| Absent | 552 (82.3) | 32 (76.2) | |
| Present | 119 (17.7) | 10 (23.8) | |
| Luminal serration | < 0.0011 | ||
| Absent | 641 (95.5) | 32 (7.2) | |
| Present | 30 (4.5) | 10 (23.8) | |
| Mucin production | 0.016 | ||
| Absent | 595 (88.7) | 32 (76.2) | |
| Present | 76 (11.3) | 10 (23.8) |
- Citation: Bae JM, Lee TH, Cho NY, Kim TY, Kang GH. Loss of CDX2 expression is associated with poor prognosis in colorectal cancer patients. World J Gastroenterol 2015; 21(5): 1457-1467
- URL: https://www.wjgnet.com/1007-9327/full/v21/i5/1457.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i5.1457