Hypoxia-inducible factor-1 modulates upregulation of mutT homolog-1 in colorectal cancer

Figure 4 Effects of siRNA of hypoxia-inducible factor-1α on tumor growth and mutT homolog-1 expression in a nude mouse xenograft tumor model. Tumor volume in the mouse interference group measured by calipers was significantly lower than that in the mock group of SW480 and HT-29 cells (A and B) (20 d: P = 0.004, P = 0.001; 48 d: P = 0.000, P = 0.000). Western blotting revealed that expression of MTH-1 protein was inhibited by silencing of HIF-1α (C). ^bP < 0.01, vs control. HIF-1α: Hypoxia-inducible factor-1α; siRNA: Small interfering RNA; MTH-1: MutT homolog-1.