Inhibition of sphingosine kinase 1 ameliorates acute liver failure by reducing high-mobility group box 1 cytoplasmic translocation in liver cells

Figure 1 Sphk1 expression in liver tissue and peripheral blood mononuclear cells of mice with D-galactosamine/lipopolysaccharide-induced acute liver failure. Acute liver failure was induced in BALB/c mice using D-galactosamine (D-GalN; 600 mg/kg) and lipopolysaccharide (LPS; 10 μg/kg). A and B: Sphk1 expression in liver tissues and PBMCs of mice with D-GalN/LPS-induced acute liver failure; C: SphK1 expression in liver tissue of mice with acute liver failure after partial deletion of KCs with GdCL3 (20 mg/kg, i.p.) for 24 h.