Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea

Table 5 TNF-α -1031 T>C, -863 C>A, -857 C>T, -308 G>A, and -238 G>A haplotypes in hepatocellular carcinoma cases and controls¹

Haplotype	Overall	Control	Case	OR (95%CI)	P-value
TNF-α -1031/-863/-857/-308/-238
T-C-C-G-G	0.5266	0.5399	0.5139	1.000 (reference)
T-C-C-G-A	0.0119	0.0000	0.0289	25.824 (1.491-447.223)	0.0005
T-C-C-A-G	0.0582	0.0486	0.0647	1.428 (0.749-2.723)	0.320
T-C-T-G-G	0.1334	0.1435	0.1232	0.891 (0.564-1.407)	0.645
T-C-T-A-G	0.0056	0.0040	0.0072	1.360 (0.190-9.764)	1.000
T-A-C-G-G	0.0171	0.0210	0.0000	0.080 (0.005-1.396)	0.023
T-A-C-G-A	0.0109	0.0025	0.0226	4.761 (0.976-23.230)	0.043
T-A-C-A-G	0.0010	0.0000	0.0066	6.796 (0.324-142.621)	0.181
T-A-T-G-G	0.0123	0.0121	0.0133	1.088 (0.288-4.118)	1.000
T-A-T-A-G	0.0009	0.0022	0.0000	0.453 (0.018-11.201)	1.000
C-C-C-G-G	0.0133	0.0103	0.0162	2.176 (0.699-6.778)	0.254
C-C-C-G-A	0.0414	0.0498	0.0318	0.605 (0.257-1.425)	0.306
C-C-T-G-A	0.0042	0.0009	0.0066	6.796 (0.324-142.600)	0.181
C-A-C-G-G	0.1631	0.1638	0.1646	1.088 (0.717-1.652)	0.749
TNF-α -1031/-857/-308/-238
T-C-G-G	0.5430	0.5637	0.5105	1.000 (reference)
T-C-G-A	0.0235	0.0060	0.0531	12.059 (2.747-52.950)	< 0.0001
TNF-α -1031/-857/-238
T-C-G	0.6026	0.6128	0.5854	1.000 (reference)
T-C-A	0.0231	0.0060	0.0517	10.696 (2.428-47.110)	0.0001
TNF-α -1031/-308/-238
T-G-G	0.6885	0.7187	0.6488	1.000 (reference)
T-G-A	0.0238	0.0063	0.0518	7.556 (2.173-26.280)	0.0002
TNF-α -1031/-238
T-G	0.7546	0.7738	0.7297	1.000 (reference)
T-A	0.0233	0.0062	0.0505	10.865 (2.473- 47.740)	0.0001

¹Only data for haplotypes significantly associated with hepatocellular carcinoma are presented in the table. Haplotypes with frequencies of less than zero among cases or controls are not shown.