Copyright
©The Author(s) 2015.
World J Gastroenterol. Nov 28, 2015; 21(44): 12519-12543
Published online Nov 28, 2015. doi: 10.3748/wjg.v21.i44.12519
Published online Nov 28, 2015. doi: 10.3748/wjg.v21.i44.12519
Figure 5 Methotrexate mode of action.
DHF: Dihydrofolate; FPGS: Folil polyglutamate synthetase; DHFPG: Dihydrofolate polyglutamates; DHFR: Dihydrofolate reductase; THF: Tetrahydrofolate; THFPG: Tetrahydrofolate polyglutamates; TS: Thymidylate synthetase; MS: Methionine synthetase; ADA: Adenosine deaminase; IMP: Inosine monophosphate; AICAR: 5-aminoimidazole-4-carbox-amide ribonucleotide.
- Citation: Quetglas EG, Mujagic Z, Wigge S, Keszthelyi D, Wachten S, Masclee A, Reinisch W. Update on pathogenesis and predictors of response of therapeutic strategies used in inflammatory bowel disease. World J Gastroenterol 2015; 21(44): 12519-12543
- URL: https://www.wjgnet.com/1007-9327/full/v21/i44/12519.htm
- DOI: https://dx.doi.org/10.3748/wjg.v21.i44.12519