Relationship between virological response and FIB-4 index in chronic hepatitis B patients with entecavir therapy

Table 2 Baseline characteristics of all populations with respect to hepatitis B virus DNA response at week 48

	Virological response at week 48
	CVR	PVR	P value
	(n = 119)	(n = 112)
Age (yr)	34.9 ± 10.9	30.2 ± 8.8	< 0.0011
Male (%)	78 (70.3)	94 (80.8)	0.16
ALT (IU/L)	120 ± 130	108 ± 88	0.05
AST (IU/L)	78 ± 87	57 ± 41	0.0011
PLT (× 109/L )	160 ± 55	175 ± 58	0.07
HBeAg-positive (%)	71 (64)	107 (89)	< 0.0012
HBV DNA	6.88 ± 1.23	7.78 ± 0.92	< 0.0012
(log10 IU/mL)
Group A (%)	55 (50)	57 (47.5)	0.75
Genotype			0.77
B	56 (51.4)	53 (48.6)
C	65 (58.5)	57 (47.5)
FIB-4 index	2.01 ± 1.43	1.21 ± 0.76	0.0031

¹This difference was no longer significant after multivariate logistic regression analysis;

²The two groups still showed a significant difference after multivariate logistic regression analysis. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PLT: Platelet; HBV: Hepatitis B virus; HBeAg: Hepatitis B e antigen.