Topic Highlight
Copyright ©The Author(s) 2015.
World J Gastroenterol. Nov 21, 2015; 21(43): 12283-12295
Published online Nov 21, 2015. doi: 10.3748/wjg.v21.i43.12283
Table 1 Cytokines related to 17 secreting helper T development and plasticity in human
CytokineEffectRef.
IL-1βAccelerate IL-17A secretion from IL-17 secreting Innate[69]
Lymphoid cells and Th17
IL-6Induce autocrine IL-21 and generation of Th17[20]
IL-10Suppress IL-17A and Th17 generation[62]
IL-12Induce IFN-γ secretion from Th17 cells (Th1/Th17 plasticity)[20]
IL-21Potentiates pathogenic effects of Th17 cells in the gut[64,65]
IL-22Attenuate the development of intestinal pathology via Stat3-mediated effects on epithelial cells[66,67]
IL-23Induce IL-22 and IL-17A secretions and maintain Th17 expansion[68]
TGF-β1Initiate generation of Treg and Th17 populations dependent on the concentration[63]