MicroRNA in inflammatory bowel disease: Translational research and clinical implication

Table 1 Aberrant microRNA expression in human colonic tissue in ulcerative colitis

Status	Tissue type	Control	Aberrant microRNA expression	Ref.
Active UC	Sigmoid, n = 15	Healthy	Decreased: miR-192 and 375	Wu et al[16], 2008
			Increased: miR-16, 21, 23a, 24, 29a, 126, 195, 422b and let-7f
	Sigmoid, n = 12	Healthy	Increased: miR-21 and 155	Takagi et al[17], 2010
	Sigmoid, n = 12	Healthy	Increased: miR-21 and 126	Feng et al[18], 2012
	Colon, nonspecific, n = 10	Healthy	Decreased: miR-188-5p, 215, 320a and 346	Fasseu et al[19], 2010
			Increased: miR-7, 31, 135b and 223
	Colon, nonspecific, n = 5	Healthy	Increased: miR-150	Bian et al[20], 2011
	Colon, nonspecific, n = 8	Healthy	Decreased: miR-143 and 145	Pekow et al[21], 2012
	Colon, nonspecific, n = 20	Healthy	Increased: miR-20b, 98 and let-7e*	Coskun et al[22], 2013
Active or inactive UC	Colon, distalmost, n = 10	Healthy	Decreased: miR-194b, 216b, 548e and 559	Lin et al[23], 2014
			Increased: miR-31, 146a, 206 and 663
Inactive UC	Sigmoid, n = 15	Healthy	Increased: miR-16, 23a, 24, 29a, 375 and 422b	Wu et al[16], 2008
	Colon, nonspecific, n = 8	Healthy	Decreased: miR-188-5p, 215, 320a and 346	Fasseu et al[19], 2010
			Increased: miR-29a, 29b, 126*, 127-3p, 196a and 324-3p
	Colon, nonspecific, n = 19	Healthy	Increased: miR-20b and 125b-1*	Coskun et al[22], 2013
Unknown	Colon, nonspecific, n = 15	Healthy	Increased: miR-21	Yang et al[24], 2013
Active UC	Colon, nonspecific, n = 20	Inactive UC	Increased: miR-98	Coskun et al[22], 2013
	Colon, left or sigmoid, n = 9	Inactive UC	Decreased: miR-196b, 489 and 630	Iborra et al[25], 2013
			Increased: miR-548a-3p and 650

UC: Ulcerative colitis.