Review
Copyright ©The Author(s) 2015.
World J Gastroenterol. Nov 14, 2015; 21(42): 12114-12124
Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.12114
Table 2 Synthetic compounds involved in matrix metalloproteinase regulation
CompoundsMechanism involvedMMPs involvedI/R modelRef.
BortezomibDownregulation of pro-inflammatory (IL-1β, TNF-α and IFN-γ) and pro-fibrotic (VEGF, TGF-β, HGF, bFGF) factorsMMP-2MMP-9Steatotic orthotopic liver transplantTiriveedhi et al[45],Transpl Immunol 2014
KMUP-1 (NO-donor)Protects from apoptosis-associated free radical generation and pro-inflammationMMP-9Hypoxic HepG2 cellsKuo et al[90], Int J Imm Pharm 2013
CS-1 peptideBlocks fibronectin α4β1 and decreases the release of pro-inflammatory mediatorsMMP-9MT-1-MMP/MMP-14Cold ischemiaDuarte et al[91],Am J Transpl 2012
CTT peptideReduction in TNF-α, IL-1, IL-2 and IFN-γMMP-9Acute small-for-size liver graftMa et al[34], Am J Transpl 2010
Cyclic RGD peptideDepresses inflammatory mediators (IFN-γ)MMP-9Steatotic Cold ischemiaFondevila et al[92],Am J Transpl 2009
ONO-1714iNOS inhibitorMMP-9Warm ischemiaHamada et al[46], Am J Pathol 2009
RXP409Inhibitory effects on MMP activityMMPsCold ischemiaDefamie et al[28],Hepatology 2008
Anti-MMP-9Decrease in expression of TNF-α, IL-2 and IFN-γMMP-9Warm ischemiaHamada et al[23], Hepatology 2008
CS-1 peptideBlocks FN α4β1 integrin and its FN ligandMMP-9Steatotic orthotopic liver transplantMoore et al[29], Am J Pathol 2007
ONO-4817Reduction in TNF-α, IL-1βMMP-2 and MMP-9Warm ischemiaShirahane et al[33],Surgery 2006
NACReduction in free radicalsMMP-9Warm ischemiaChen et al[93], Transpl Proc 2005
BB3103Prostaglandin PGE(1) protectionMMP-2Cold ischemiaYang et al[94], Microvasc Res 2002
RXPO3Protects from necrosis/apoptosisMMP-3-9-11-13Warm ischemiaCursio et al[24], FASEB J 2002