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Copyright ©The Author(s) 2015.
World J Gastroenterol. Nov 14, 2015; 21(42): 11931-11940
Published online Nov 14, 2015. doi: 10.3748/wjg.v21.i42.11931
Table 1 The studies evaluating the role of anti-HBc in the development of cirrhosis in HBsAg-negative patients with chronic hepatitis C
First author, yearNo. of patientsCountryType of studyCirrhosis, positive/tested, n/n (%)
P value
HBcAb+HBcAb-
Verbaan 1998[63]99SwedenCross-sectional10/44 (22.7)10/55 (18.2)NS
De Maria 2000[37]285United StatesCross-sectional29/90 (32.2)41/195 (21.0)< 0.05
Sagnelli 2000[24]174ItalyCase-control9/76 (11.8)6/98 (6.1)< 0.005
Giannini 2003[38]119ItalyCross-sectional20/48 (41.6)15/71 (21.0)0.020
Dinis-Ribeiro 2005[59]129PortugalCross-sectional14/30 (46.6)32/99 (32.3)HR:1.35 (1.01-2.69)1
Helmy 2006[64]169Saudi ArabiaCross-sectional14/85 (16.5)45/84 (53.6)0.0001
Laguno 2008[65]238SpainCross-sectional78/142 (55)249/96 (51)20.720
Carvalho-Filho 2009[60]111BrazilCross-sectional24/31 (77.4)340/80 (50.0)30.017
El-Sherif 2009[61]100EgyptCross-sectional68/71 (95.8)23/29 (79.3)0.009
Levast 2010[66]140FranceCross-sectional5/45 (11.1)16/95 (16.8)NS
Coppola 2014[62]222ItalyCross-sectional21/77 (27.3)12/145 (8.3)< 0.009