Colorectal cancer: Metastases to a single organ

Table 2 Retrospective studies of patients with unresected liver metastases

Ref.	Patients without extrahepatic metastases, n	The extent of liver involvement	Median overall survival (mo)	Treatments
Yamamura et al[41], 1997 (n = 73)	67	Metastases in one lobe	13	Chemotherapy (chemotherapy did not significantly affect survival in multivariate analysis)
		Less than four metastases in both lobes	12
		More than five metastases in both lobes	6
Stangl et al[39], 1994	189	≤ 25%	11.1	No treatment
		> 25%	6.3
Chang et al[38], 1989 (n = 67)	49		15.1	Floxuridine (hepatic arterial or intravenously)
		< 25%	23.8
		25%-75%	14.8
		> 75%	7.3
Arnaud et al[40], 1984 (n = 56)	(not specified)	One lobe	17	NA
		Both lobes	8.23
Johnson et al[42], 1981	51	Solitary liver metastasis (n = 12)	18	NA
		Multiple metastases in one lobe (n = 6)	7
		Multiple metastases in both lobes (n = 33)	8

mOS: Median overall survival; NA: Not available.