Non-invasive diagnosis of liver fibrosis and cirrhosis

Table 2 Diagnostic accuracy of selected experimental serum markers

Marker	Prognosis	Sensitivity	Specificity	AUROC
PIIINP	Significant fibrosis	74	75	0.72
	Cirrhosis	64	66	0.76
PINP	Significant fibrosis	70	73	-
	Cirrhosis	63	73	-
YKL-40	Significant fibrosis	78	81	0.81
	Cirrhosis	80	71	0.80
TIMP	Significant fibrosis	66	72	0.71
	Cirrhosis	91	65	0.90
sH2a + ALT1	Significant fibrosis	65	85	0.79
	Advanced fibrosis and cirrhosis	-	-	0.86

¹Except for these values, which were taken from Ref. [87], all other values are medians from Ref. [11]. PIIINP: N-terminal pro-peptide of collagen type III; PINP: N-terminal propeptide of collagen type I; TIMP: Tissue inhibitor of metalloproteinase; sH2a: Soluble H2a; ALT: Alanine aminotransferase.