Current stage in inflammatory bowel disease: What is next?

Table 2 Genetic association studies of adverse events secondary to azathioprine in inflammatory bowel disease patients

Study (year)	No. of patients	Conclusion
Marinaki et al[34] (2004)	130	Significant association with flu-illness, rash, and pancreatitis
		No association with mielotoxicity
Allorge et al[35] (2005)	72	No association with flu-illness, rash, pancreatitis, or mielotoxicity
Gearry et al[36] (2004)	147	No association with flu-illness, rash, and pancreatitis
De Ridder et al[37] (2006)	72	No association with side effects
Hindorf et al[38] (2006)	60	No association with side effects
von Ahsen et al[39] (2005)	71	Early withdrawal of therapy but no association with specific adverse events
Ansari et al[40] (2008)	202	Association with flu-like symptoms but not withdrawal of therapy
van Dieren et al[41] (2005)	109	Not associated with an increased risk for the development of leucopenia and other side effects
Zelinkova et al[42] (2006)	262	Increased risk of leucopenia
Uchiyama et al[43] (2009)	16	Increase risk of mielotoxicity (leucopenia)
Shipkova et al[44] (2011)	160	Increase risk of mielotoxicity
Kim et al[45] (2010)	248	No association with leucopenia
Zabala-Fernández et al[46] (2011)	232	Significant association with artralgia