Disease monitoring in inflammatory bowel disease

Table 6 Calculated fecal calprotectin cutoffs based on endoscopic score

Ref.	Disease	Endoscopic tool	Score	FC cutoff	Sensitivity(%)	Specificity(%)	PPV(%)	NPV(%)
Guidi et al[111]	UC/CD	CDEIS	< 3 (mucosal healing)	121 μg/ga	79	57	-	-
D’Haens et al[64]	CD	CDEIS	< 3 (inactive)	250 μg/g	94.1	62.2	48.5	96.6
	UC	Mayo	1-3 (any inflammation)	250 μg/g	71	100	100	47.1
Sipponen et al[88]	CD	CDEIS	≥ 3 (active)	200 μg/g	87	100	100	70
af Björkesten et al[25]	CD	SES-CD	0 (inactive)	94 μg/g	82	78	-	-
Lobatón et al[48]	UC	Mayo	0-1 (inactive-mild)1	250 μg/g1b	73.5	89.7	86.2	79.5
			0-1 (inactive-mild)2	280 μg/g2b	75.4	89.1	86	80.3
Takashima et al[67]	UC	Mayo	0 (inactive)	250 μg/g	82	62	61	83

¹FC-ELISA;

²FC-POCT;

^aP = 0.038;

^bP < 0.001 vs control. CDEIS: Crohn’s disease endoscopic index of severity; SES-CD: Simple endoscopic score for Crohn’s disease; FC: Fecal calprotectin.