Impact of discontinuing non-steroidal antiinflammatory drugs on long-term recurrence in colonic diverticular bleeding

Table 1 Baseline characteristics of the study cohort (n = 132) n (%)

Characteristic	Value
Mean age (mean ± SD), yr	70 ± 12
Age > 70 yr	70 (53)
Sex, male	87 (66)
Anatomical distribution of diverticula
Right-sided type	42 (32)
Left-sided typ	27 (20)
Bilateral type	63 (48)
Definite diagnosis (stigmata of recent hemorrhage)	23 (17)
Presumptive diagnosis	109 (83)
Transfusion requirement during hospitalization	37 (28)
Mean units of transfused blood per patient1± SD	8.0 ± 6.0
Current drinker	126 (95)
Current smoker	36 (27)
NSAID2 users on admission	41 (27)
Discontinuing NSAID users at discharge	26 (20)
Continuing NSAID users at discharge	15 (11)
Low-dose aspirin2 users on admission	29 (22)
Low-dose aspirin users at discharge	29 (22)
Non-aspirin antiplatelet2 users on admission	27 (21)
Non-aspirin antiplatelet users at discharge	27 (21)
Anticoagulant2 users on admission	9 (6.8)
Anticoagulant users at discharge	9 (6.8)
Acetaminophen users on admission	2 (1.5)
Acetaminophen users at discharge	13 (9.9)
Corticosteroid users on admission	4 (3.0)
Corticosteroid users at discharge	5 (3.3)
Hypertension	83 (63)
Diabetes mellitus	27 (20)
Dyslipidemia	29 (22)
Cardiovascular disease	33 (25)
Cerebrovascular disease	2 (1.5)
Chronic liver disease	5 (3.8)
Hemodialysis	7 (5.3)

¹Analysis of patients who received transfusion.

²Non-selective NSAIDs included loxoprofen, diclofenac, naproxen, etodolac, zaltoprofen, meloxicam, lornoxicam, and celecoxib (n = 3). Distribution type was defined as follows: right-sided, involving the transverse or proximal colon; left-sided, involving the descending or distal colon; or bilateral, involving the entire colon. Low-dose aspirin included enteric-coated aspirin (100 mg) and buffered aspirin (81 mg). Non-aspirin antiplatelet agents included ticlopidine, clopidogrel, cilostazol, dipyridamole, sarpogrelate hydrochloride, ethyl icosapentate, dilazep, limaprost, and beraprost. Anticoagulants included warfarin and dabigatran etexilate. NSAIDs: Non-steroidal anti-inflammatory drugs.