Survival in gastric cancer in relation to postoperative adjuvant therapy and determinants

Table 5 Multivariate Cox regression analysis for the correlates of local recurrence free, distant metastasis free and overall survival

	Local recurrence free survival						Distant metastasis free survival						Overall survival
	Before 2008		2008-2010		Overall		Before 2008		2008-2010		Overall		Before 2008		2008-2010		Overall
	Sig.	Exp(B)	Sig.	Exp(B)	Sig.	Exp(B)	Sig.	Exp(B)	Sig.	Exp(B)	Sig.	Exp(B)	Sig.	Exp(B)	Sig.	Exp(B)	Sig.	Exp(B)
Age (yr)
< 50 vs > 50	0.748	1.191			0.387	1.468							0.122	1.742
Operaton type
Total vs subtotal			0.118	0.284											0.147	0.426
Vascular involvement
Yes vs No			0.748	0.707									0.099	2.375			0.085	2.106
Perinueral involvement
Yes vs No													0.656	0.820			0.326	0.707
T stage	0.772				0.318								0.781				0.762
T1	0.938	10856.260			0.936	18774.638							0.995	0.995			0.967	0.967
T2	0.934	21845.678			0.935	23091.062							0.674	1.425			0.651	1.447
T3	0.933	24325.273			0.928	62667.340							0.969	0.962			0.734	1.369
LN1
< 15 vs > 16	0.458	2.278					0.722	0.863
LN2
< 10 vs > 11	0.073	0.146
Nodal stage (AJCC 2010)	0.782				0.167		0.994				0.052		0.033				0.104
N1	0.255	3.526			0.217	2.748	0.754	1.196			0.831	1.118	0.404	1.624			0.162	2.184
N2	0.232	3.853			0.0421	4.959	0.969	1.025			0.313	1.614	0.122	2.439			0.0091	4.056
N3a	0.452	3.407			0.786	1.380	0.814	1.266			0.014	3.218	0.0061	5.132			0.059	4.733
N3b	0.344	5.380			0.502	2.330	0.761	1.471			0.060	3.446	0.0271	5.263			0.098	4.292
İnvolved lymph nodes (n)
≤ 5 vs > 5	0.464	2.322			0.242	2.573	0.283	2.677	0.207	2.245					0.303	1.742	0.726	1.245
Significance of the model	P = 0.053		P = 0.218		P = 0.017		P = 0.153		P = 0.196		P = 0.054		P = 0.001		P = 0.151		P < 0.0011

¹Indicate statistical significance at α = 0.05 level. Only the variables with P < 0.2 significance in the univariate analysis were included into the Cox-regression model on the basis of Hosmer-Lemeshow method. Since both American Joint Commission on Cancer (AJCC) 2002 and 2010 nodal staging variables met the criteria to be included in the multivariate analysis, only AJCC 2010 nodal staging was included.