Preoperative CA 125 is significant indicator of curative resection in gastric cancer patients

Table 3 Univariateand multivariate analysis of prognostic risk factors for disease-free survival after curative operations

Variables	Univariate analysis		Multivariate analysis
	5-year DFS	P value	HR (95%CI)	P value
Age, yr		0.865		0.282
< 60 (n =272)	78.3%
≥ 60 (n = 364)	80.1%		1.250 (0.833-1.877)
Sex		0.194		0.037
Male (n = 417)	78.3%
Female (n = 219)	81.7%		0.616 (0.391-0.971)
Differentiation		0.020		0.292
Differentiated (n = 382)	81.6%
Undifferentiated (n = 254)	75.6%		0.797 ( 0.524-1.215)
Location		0.004		0.454
Lower 1/3 (n = 359)	76.0%
Middle 1/3 (n = 212)	86.8%		0.797 (0.489-1.297)
Upper 1/3 (n = 60)	70.8%		1.172 (0.643-2.135)
Whole (n = 5)	40.0%		0.487 (0.138-1.720)
Lymphovascular invasion		< 0.001		0.709
Negative (n = 513)	81.8%
Positive (n = 123)	69.4%		1.085 (0.708-1.662)
Perineural invasion		< 0.001		0.072
Negative (n = 582)	81.4%
Positive (n = 54)	54.4%		1.629 (0.958-2.770)
Stage		< 0.001		< 0.001
IA (n = 292)	98.7%
IB (n = 102)	89.4%		6.613 (1.703-25.674)	0.006
II (n = 75)	79.8%		15.415 (4.297-55.300)	< 0.001
IIIA (n = 69)	49.5%		43.857 (12.999-147.966)	< 0.001
IIIB (n = 39)	46.2%		66.090 (18.643-234.289)	< 0.001
IV (n = 59)	32.7%		93.720 (27.252-319.103)	< 0.001
CEA		< 0.001		0.073
Negative (n = 579)	82.1%		1.559 (0.959-2.535)
Positive (n = 57)	51.3%
CA 19-9		< 0.001		0.694
Negative (n = 586)	81.7%
Positive (n = 50)	51.7%		0.901 (0.535-1.516)
CA 125		< 0.001		0.020
Negative (n = 616)	80.6%
Positive (n = 20)	30.8%		2.431 (1.153-5.123)