Endocrine causes of nonalcoholic fatty liver disease

Figure 2 Schematic summary of nonalcoholic fatty liver disease pathophysiology according to the “two-hit hypothesis”. VAT: Visceral adipose tissue; FFA: Free fatty acid; TG: Triglycerides; PAI-1: Plasminogen activator inhibitor-1; TNF-α: Tumor necrosis factor α; IL-6: Interleukin 6; ROS: Reactive oxygen species; TLR-4: Toll-like receptor 4; DAG: Diacylglycerols; ER: Endoplasmic reticulum; NASH: Non-alcoholic steatohepatitis; HCC: Hepatocellular carcinoma; PNPLA3: Patatin-like phospholipase domain-containing protein 3; NF-κB: Nuclear factor-kappa B; JNK: c-Jun N-terminal kinases; HSC: Hepatic stellate cells.