Non-invasive assessment of liver fibrosis in patients with alcoholic liver disease

Table 1 Non-invasive serum tests for the assessment of liver fibrosis and corresponding stages of alcoholic liver disease diagnosed

Test	Variables	ALD stage assessed
AST:ALT ratio	ALT, AST	≥ F1, F4
HA	HA	F4
PGA	PT, GGT, apolipoprotein-A1	F4
PGAA	PT, GGT, apolipoprotein-A1, α2-macroglobulin
FibroTest®	Haptoglobin, α2-macroglobulin, apolipoprotein-A1, bilirubin, GGT	≥ F3, F4
FibrometerA®	Age, weight, glucose, AST, ALT, PLT count, ferritin	≥ F3, F4
FIB-4	Age, AST, ALT, platelet count	≥ F3
Hepascore®	Age, sex, bilirubin, GGT, α2-macroglobulin, HA	≥ F3, F4
APRI	AST, platelet count	≥ F2, F4
ELF test™	HA, PIIINP, TIMP-1	≥ F3, F4
Forns index	Age, platelet count, total cholesterol, GGT	≥ F3, F4

ALD: Alcoholic liver disease; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; PT: Prothrombin time; GGT: γ-glutamyl transpeptidase; PLT: Platelets; PIIINP: Terminal peptide of procollagen III; TIMP-1: Tissue inhibitor of metalloproteinase 1; HA: Hyaluronic acid.