Are probiotics useful in Helicobacter pylori eradication?

doi:10.3748/wjg.v21.i37.10644

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World Journal of Gastroenterology

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1007-9327

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World J Gastroenterol. Oct 7, 2015; 21(37): 10644-10653
Published online Oct 7, 2015. doi: 10.3748/wjg.v21.i37.10644

Table 1 Probiotics as adjuvant therapy in Helicobacter pylori eradication protocols

Ref.	Therapy		Study		Eradication rate		Adverse effects
Ref.	Eradication therapy (d)	Probiotic therapy(d)	No. pts	Reass. ofH. pylori	H. pylori + probiotic therapy	H. pylori therapy	H. pylori + probiotic therapy	H. pylori therapy
Cindoruk et al[79]	PPI + AC (14)	S. boulardii (14)	124	UBT	44/62¹	37/62	14/62¹	37/62
Cremonini et al[71]	PPI + CT (7)	S. boulardii (14)	43	UBT	17/20	16/20	3/21¹	12/20
Duman et al[80]	PPI + AC (14)	S. boulardii (14)	389	-	-	-	17/204¹	31/185
Hurduc et al[81]	PPI + AC (10)	S. boulardii (28)	90	UBT, hist.	45/48	34/42	4/48¹	13/42
Song et al[65]	PPI + AC (7)	S. boulardii (28)	661	UBT	264/330	237/331	48/330¹	63/331
Zojaji et al[66]	PPI + AC (14)	S. boulardii (14)	160	UBT	75/80	65/80	14/80¹	29/80
Canducci et al[67]	PPI + AC (7)	L. acidophilus (7 )	120	UBT	42/60¹	52/60	-	-
Sýkora et al[69]	PPI + AC (7)	L. casei (14)	86	UBT	33/39¹	27/47	7/39	9/47
Armuzzi et al[68]	PPI + CT (7)	L. GG (14)	60	UBT	25/30	24/30	12/30¹	20/30
Szajewska et al[70]	PPI + AC (7)	L. GG (14)	83	UBT, hist., RUT	23/34	22/32	18/35	13/32
Cremonini et al[71]	PPI + CT (7)	L. GG (14)	85	UBT	16/21	16/20	3/20¹	12/20
Ojetti et al[72]	PPI + AL	L. reuteri (14 )	90	UBT	36/45¹	27/45	10/45¹	26/45
Lionetti et al[73]	PPI + ACT (10)	L. reuteri (20 )	42	UBT	17/20	16/20	3/20¹	9/20
Francavilla et al[57]	PPI + (7)	L. reuteri (2 strains) (60)	100	UBT
Emara et al[74]	PPI + AC (14)	L. reuteri (28)	70	hist., RUT	26/35	23/35	10/35¹	24/35
Sheu et al[75]	PPI + AC (7)	B. animalis, L. casei (35)	160	hist., RUT, UBT	73/80¹	63/80	15/80¹	53/80
Goldman et al[76]	PPI + AC (7)	B. animalis, L. casei (90)	65	UBT	14/33	13/32	-	-
Deguchi et al[77]	PPI + AC (7)	L. gasseri (28)	229	UBT	95/111¹	79/106	-	-
Nista et al[78]	PPI + AC (7)	B. clausii (14)	120	UBT	39/50	37/50	21/50¹	30/50

¹Statistically significant (P < 0.05). -: Data are not available; p: Pediatric study; Pts.: Patients; Reass.: Reassessment; PPI: Proton pump inhibitor: UBT: Urea breath test; Hist.: Histology; RUT: Rapid urease test; A: Amoxicillin; C: Clarithromycin; T: Tinidazole; L: Levofloxacin.

Citation: Homan M, Orel R. Are probiotics useful in Helicobacter pylori eradication? World J Gastroenterol 2015; 21(37): 10644-10653
URL: https://www.wjgnet.com/1007-9327/full/v21/i37/10644.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i37.10644