Challenges of deciphering gastric cancer heterogeneity

doi:10.3748/wjg.v21.i37.10510

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2015; 21(37): 10510-10527
Published online Oct 7, 2015. doi: 10.3748/wjg.v21.i37.10510

Table 1 Selection of commonly altered microRNAs in the peripheral blood of gastric cancer patients

miRNA	Alteration	Sensitivity (%)	Specificity (%)	Ref.
miR1-8a	Up-regulated	80.5	84.6	[125]
miR-21	Up-regulated	-¹	-¹	[134,202-205]
miR-187	Up-regulated	82.5	60.98	[133]
miR-199a-3p	Up-regulated	80.0	74.0	[206,207]
miR-200c	Up-regulated	65.4	100.0	[122]
miR-371-5p	Up-regulated	75.0	63.4	[133]
miR-378	Up-regulated	87.5	70.7	[133]
miR-451	Up-regulated	96.0	100.0	[208]
miR-486	Up-regulated	86.0	97.0	[208]
miR-223 and miR-21, miR-218	miR-223 and miR-21 were up-regulated, miR-218 was down-regulated	84.3	92.9	[203]
miR-1, miR-20a, miR-27a, miR-34 and miR-423-5p	Up-regulated	80.0	81.0	[209]
miR-221, miR-744, and miR-376c	Up-regulated	82.4	58.8	[210]
miR-375, miR-142-5p	Up-regulated	> 85.0	> 85.0	[211]
miR-19b-3p, miR-16-5p	Up-regulated	49.0	91.0	[212]
miR-19b-3p, miR-16-5p	Up-regulated	81.3	58.6	[212]

¹Different studies reported different sensitivity and specificity values.

Citation: Hudler P. Challenges of deciphering gastric cancer heterogeneity. World J Gastroenterol 2015; 21(37): 10510-10527
URL: https://www.wjgnet.com/1007-9327/full/v21/i37/10510.htm
DOI: https://dx.doi.org/10.3748/wjg.v21.i37.10510