Ursodeoxycholic acid induces apoptosis in hepatocellular carcinoma xenografts in mice

Figure 6 Ursodeoxycholic acid induces BAX but suppresses BCL2 protein levels. Western blot analysis for the expression of BAX and BCL2 proteins was performed with protein lysates prepared from control and treated xenografts. 0: control; lanes 1-3: ursodeoxycholic acid (UDCA) 30 mg/kg per day, UDCA 50 mg/kg per day, and UDCA 70 mg/kg per day. β-actin was used as an internal control.